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| MMDB Description | |
|---|---|
| 11947 | Structure-based Design and Synthesis of Lipophilic 2,4- Diamino-6-substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductase and Potential Antitumor Agents |
| 752 | Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed With Folate and 5-deazofolate |
| 55930 | Methotrexate-resistant Variants of Human Dihydrofolate Reductase With Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers |
| 55931 | Methotrexate-resistant Variants of Human Dihydrofolate Reductase With Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers |
| 55965 | Crystal Structure of Human Dihydrofolate Reductase Complexed With Folate |
| 56332 | Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase With Nadph and a Classical Antitumor Furopyrimdine |
| 56333 | Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase With Nadph and a Classical Antitumor Furopyrimdine |
| 56334 | Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase With Nadph and a Classical Antitumor Furopyrimdine |
| 20168 | Human Dihydrofolate Reductase Complexed With Nadph and 6- ([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3- D]pyrimidine (Sri-9439), a Lipophilic Antifolate |
| 20169 | Human Dihydrofolate Reductase Complexed With Nadph and (Z)- 6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5- Methylpyrido[2,3-d]pyrimidine (Sri-9662), a Lipophilic Antifolate |
| 22352 | Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex With Human Dihydrofolate Reductase |
| 22353 | Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex With Human Dihydrofolate Reductase |
| 57029 | Human Dihydrofolate Reductase, Monoclinic (P21) Crystal Form |
| 57030 | Human Dihydrofolate Reductase, Orthorhombic (P21 21 21) Crystal Form |
| 25683 | Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase |
| 25684 | Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase |
| 25685 | Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase |
| 26995 | Structure Determination of Tetrahydroquinazoline Antifolates in Complex With Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry |
| 26996 | Structure Determination of Tetrahydroquinazoline Antifolates in Complex With Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry |
| 26997 | Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex With Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry |
| 31293 | Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22arg Variant Mouse and Human Dihydrofolate Reductase |
| 31294 | Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes With Methotrexate and Nadph |
| 31295 | Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes With Methotrexate and Nadph |
| 35994 | Solution Structure of Human Dihydrofolate Reductase Complexed With Trimethoprim and Nadph, 25 Structures |
| 45877 | Human Dihydrofolate Reductase Complexed With Nadph and 2,4- Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate |
| 45878 | Human Dihydrofolate Reductase Complexed With Nadph and 2,4- Diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6- Methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate |
| 2643 | Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed With Folate and 5-deazofolate |
| 43321 | NEW Insights Into Dhfr Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes With Nadph and Two Highly Potent Trimethoprim Derivatives |
| 78125 | Human Dihydrofolate Reductase Complexed With Nadph and Trimethoprim |
| 78126 | Human Dihydrofolate Reductase Complexed With Nadph and a Lipophilic Antifolate Selective for Mycobacterium Avium Dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- Methylpyrido(2,3-d)pyrimidine (Sri-8686) |
| 78127 | Human Dihydrofolate Reductase Complexed With Nadph and Folate |
| 66908 | Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase With Nadph and a Ternary Complex Wtih the Potent and Selective Inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl) Methylpteridine |
| 66909 | Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase With Nadph and a Ternary Complex With the Potent and Selective Inhibitor 2.4-diamino-6-(-2'-hydroxydibenz[b,f]azepin-5- Yl)methylpteridine |
| 72890 | Crystal Structure of a Methotrexate-resistant Mutant of Human Dihydrofolate Reductase |
| 76069 | Correlations of Human Dihydrofolate Reductase With Structural Data for Human Active Site Mutant Enzyme Complexes |
| 76070 | Human Dihydrofolate Reductase Structural Data With Active Site Mutant Enzyme Complexes |
| 76071 | Structural Data for Human Active Site Mutant Enzyme Complexes |
| 76079 | Correlations of Inhibitor Kinetics for Pneumocystis Jirovecii and Human Dihydrofolate Reductase With Structural Data for Human Active Site Mutant Enzyme Complexes |
| 76848 | Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3- D]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agenst |
| 76849 | Human Dihydrofolate Reductase Q35kn64f Double Mutant Inhibitor Complex |
| 76850 | Human Dihydrofolate Reductase Inhibitor Complex |
| 77015 | Human Dihydrofolate Reductase Q35k Mutant Inhibitor Complex |
| 77812 | Human Dhfr With Z-isomer in Orthorhombic Lattice |
| 77391 | Alternate Binding Modes Observed for the E- and Z-isomers of 2,4- Diaminofuro[2,3d]pyrimidines as Ternary Complexes With Nadph and Mouse Dihydrofolate Reductase |
| 77392 | Alternate Binding Modes Observed for the E- and Z-isomers of 2,4- Diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Mouse Dihydrofolate Reductase |
| 87683 | Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis Jirovecii, Pneumocystis Carinii and Human Dihydrofolate Reductase and Their Active Site Mutants |
| 90788 | Design, Synthesis, Biological Evaluation and X-ray Crystal Structures of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors |
| 90789 | Design, Synthesis, Biological Evaluation and X-ray Crystal Structure of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors |
| 86622 | Perferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase |
| 86623 | Perferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase |
| 86624 | Preferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase |
| 86625 | Preferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase |
| 87335 | Preferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase |
| 87336 | Preferential Selection of Isomer Binding From Chiral Mixtures: Alernate Binding Modes Observed FRO the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase |
| 87614 | Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes With Nadph and a Series of Five 5-(omega-carboxy(alkyloxy(pyrido[2,3- D]pyrimidine Derivatives |